| 11. Jornada | 08.11.2020 | Dinamo Zagreb | - | NK Istra 1961 | 5:0 | ||||
| 9. Jornada | 25.11.2020 | NK Istra 1961 | - | NK Osijek | 1:4 |  |
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| 13. Jornada | 28.11.2020 | NK Varaždin | - | NK Istra 1961 | 1:1 | |
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| 12. Jornada | 27.01.2021 | NK Istra 1961 | - | HNK Rijeka | 1:2 | ||||
| 18. Jornada | 30.01.2021 | NK Osijek | - | NK Istra 1961 | 1:0 | ||||
| 19. Jornada | 03.02.2021 | Hajduk Split | - | NK Istra 1961 | 1:0 | ||||
| 20. Jornada | 07.02.2021 | NK Istra 1961 | - | Dinamo Zagreb | 0:1 | |
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| 23. Jornada | 28.02.2021 | HNK Gorica | - | NK Istra 1961 | 2:1 | |
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| 24. Jornada | 05.03.2021 | NK Istra 1961 | - | HNK Šibenik | 3:2 | ||||
| 25. Jornada | 13.03.2021 | Lokomotiva Zagreb | - | NK Istra 1961 | 0:1 | ||||
| 27. Jornada | 03.04.2021 | NK Istra 1961 | - | NK Osijek | 0:2 | ||||
| 31. Jornada | 26.04.2021 | NK Varaždin | - | NK Istra 1961 | 1:1 | ||||
| 33. Jornada | 07.05.2021 | HNK Šibenik | - | NK Istra 1961 | 1:0 | ||||
| 35. Jornada | 15.05.2021 | NK Istra 1961 | - | Slaven Belupo | 1:0 |
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