| 7. Jornada | 04.09.2021 | Leones FC | - | Unión Magdalena | 3:0 | ||||
| 8. Jornada | 13.09.2021 | Boca Juniors de Cali | - | Leones FC | 1:5 | ||||
| 9. Jornada | 19.09.2021 | Leones FC | - | Real Cartagena | 2:0 | ||||
| 11. Jornada | 04.10.2021 | Llaneros FC | - | Leones FC | 4:3 | ||||
| 12. Jornada | 12.10.2021 | Leones FC | - | Tigres FC | 2:0 | ||||
| 13. Jornada | 19.10.2021 | Barranquilla FC | - | Leones FC | 0:1 | ||||
| 14. Jornada | 24.10.2021 | Leones FC | - | Bogotá FC | 1:0 | ||||
| 15. Jornada | 30.10.2021 | Atlético FC | - | Leones FC | 1:3 |
Colombia