| 4. Jornada | 31.07.2022 | Cumbayá | - | Mushuc Runa | 1:1 | ||||
| 5. Jornada | 08.08.2022 | Barcelona | - | Mushuc Runa | 4:1 | ||||
| 8. Jornada | 28.08.2022 | Mushuc Runa | - | Gualaceo SC | 2:0 | ||||
| 10. Jornada | 10.09.2022 | Mushuc Runa | - | LDU Quito | 1:2 |  |
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| 11. Jornada | 20.09.2022 | Guayaquil City | - | Mushuc Runa | 4:1 | |
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| 7. Jornada | 25.09.2022 | Delfín SC | - | Mushuc Runa | 0:0 | ||||
| 12. Jornada | 02.10.2022 | Mushuc Runa | - | Emelec | 0:0 | ||||
| 13. Jornada | 09.10.2022 | Aucas | - | Mushuc Runa | 0:0 | |
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| 14. Jornada | 17.10.2022 | Mushuc Runa | - | Independiente del Valle | 0:1 | ||||
| 15. Jornada | 22.10.2022 | Deportivo Cuenca | - | Mushuc Runa | 3:1 | |
Ecuador