| 1. Jornada | 11.07.2022 | Diriangén FC | - | Matagalpa FC | 2:0 |  |
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| 2. Jornada | 17.07.2022 | Matagalpa FC | - | ART Municipal Jalapa | 0:0 | |
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| 3. Jornada | 25.07.2022 | Juventus Managua | - | Matagalpa FC | 3:2 | |
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| 4. Jornada | 31.07.2022 | Matagalpa FC | - | H&H Export Sébaco | 1:2 |  |
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| 7. Jornada | 14.08.2022 | UNAN Managua | - | Matagalpa FC | 3:0 | |
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| 9. Jornada | 28.08.2022 | Matagalpa FC | - | Real Estelí FC | 0:3 | ||||
| 12. Jornada | 01.10.2022 | Matagalpa FC | - | Juventus Managua | 2:5 | ||||
| 13. Jornada | 23.10.2022 | H&H Export Sébaco | - | Matagalpa FC | 2:1 | |
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| 15. Jornada | 30.10.2022 | CD Walter Ferretti | - | Matagalpa FC | 1:0 | |
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| 17. Jornada | 27.11.2022 | Managua FC | - | Matagalpa FC | 2:1 | ||||
| 18. Jornada | 02.12.2022 | Real Estelí FC | - | Matagalpa FC | 6:0 | |
Nicaragua