| 1. Jornada | 19.01.2025 | Matagalpa FC | - | Diriangén FC | 0:4 | ||||
| 3. Jornada | 26.01.2025 | Real Estelí FC | - | Matagalpa FC | 2:0 |  |
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| 7. Jornada | 17.02.2025 | Managua FC | - | Matagalpa FC | 1:0 | ||||
| 8. Jornada | 19.02.2025 | Matagalpa FC | - | UNAN Managua | 2:2 | ||||
| 9. Jornada | 22.02.2025 | Matagalpa FC | - | ART Municipal Jalapa | 3:3 | ||||
| 4. Jornada | 26.02.2025 | Matagalpa FC | - | Rancho Santana | 2:1 | ||||
| 10. Jornada | 03.03.2025 | Diriangén FC | - | Matagalpa FC | 3:1 | ||||
| 11. Jornada | 08.03.2025 | Matagalpa FC | - | Club Deportivo Ocotal | 3:0 | ||||
| 12. Jornada | 12.03.2025 | Matagalpa FC | - | Real Estelí FC | 2:4 |  |
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| 13. Jornada | 23.03.2025 | Rancho Santana | - | Matagalpa FC | 1:1 | ||||
| 14. Jornada | 30.03.2025 | Matagalpa FC | - | H&H Export Sébaco | 5:2 | ||||
| 15. Jornada | 08.04.2025 | CD Walter Ferretti | - | Matagalpa FC | 0:0 | ||||
| 17. Jornada | 27.04.2025 | UNAN Managua | - | Matagalpa FC | 1:1 | ||||
| 18. Jornada | 02.05.2025 | ART Municipal Jalapa | - | Matagalpa FC | 3:0 |
Nicaragua