| 1. Jornada | 31.07.2021 | Diriangén FC | - | UNAN Managua | 2:1 | ||||
| 2. Jornada | 10.08.2021 | UNAN Managua | - | H&H Export Sébaco | 0:2 |  |
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| 3. Jornada | 15.08.2021 | UNAN Managua | - | ART Municipal Jalapa | 1:0 | ||||
| 4. Jornada | 23.08.2021 | UNAN Managua | - | Real Madriz | 3:5 |  |
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| 5. Jornada | 30.08.2021 | CD Walter Ferretti | - | UNAN Managua | 1:1 | |
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| 6. Jornada | 02.09.2021 | Real Estelí FC | - | UNAN Managua | 4:1 | ||||
| 9. Jornada | 27.09.2021 | UNAN Managua | - | Juventus Managua | 1:1 | |
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| 10. Jornada | 02.10.2021 | UNAN Managua | - | Diriangén FC | 0:5 | ||||
| 12. Jornada | 18.10.2021 | ART Municipal Jalapa | - | UNAN Managua | 2:2 | |
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| 14. Jornada | 25.10.2021 | UNAN Managua | - | CD Walter Ferretti | 0:1 | ||||
| 15. Jornada | 31.10.2021 | Managua FC | - | UNAN Managua | 3:0 | ||||
| 16. Jornada | 04.11.2021 | UNAN Managua | - | Real Estelí FC | 3:3 | |
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| 17. Jornada | 19.11.2021 | UNAN Managua | - | Club Deportivo Ocotal | 2:3 | |
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| 18. Jornada | 22.11.2021 | Juventus Managua | - | UNAN Managua | 1:2 |
Nicaragua