| 2. Jornada | 26.08.2017 | CA Cerro | - | Defensor Sporting | 0:3 |  |
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| 3. Jornada | 03.09.2017 | Defensor Sporting | - | Sud América | 3:2 | |
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| 4. Jornada | 09.09.2017 | Juventud de Las Piedras | - | Defensor Sporting | 0:1 | |
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| 5. Jornada | 16.09.2017 | Defensor Sporting | - | Danubio | 1:0 | |
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| 6. Jornada | 08.10.2017 | Plaza Colonia | - | Defensor Sporting | 1:2 | ||||
| 7. Jornada | 14.10.2017 | Defensor Sporting | - | River Plate | 2:1 | |
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| 8. Jornada | 05.11.2017 | Peñarol | - | Defensor Sporting | 3:1 | ||||
| 9. Jornada | 08.11.2017 | Defensor Sporting | - | Racing | 4:2 | |
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| 10. Jornada | 12.11.2017 | El Tanque Sisley | - | Defensor Sporting | 0:2 | |
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| 11. Jornada | 16.11.2017 | Defensor Sporting | - | Liverpool | 2:2 | |
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| 13. Jornada | 23.11.2017 | Defensor Sporting | - | Montevideo Wanderers | 2:1 | ||||
| 14. Jornada | 26.11.2017 | Nacional | - | Defensor Sporting | 1:1 | |
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| 15. Jornada | 03.12.2017 | Defensor Sporting | - | Fénix | 0:2 |
Uruguay