| 1. Jornada | 24.07.2021 | Oud-Heverlee Leuven | - | SV Zulte Waregem | 1:1 |  |
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| 5. Jornada | 22.08.2021 | SV Zulte Waregem | - | Sporting Charleroi | 2:2 | ||||
| 6. Jornada | 29.08.2021 | KV Oostende | - | SV Zulte Waregem | 0:2 | |
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| 7. Jornada | 11.09.2021 | SV Zulte Waregem | - | Cercle Brugge | 2:4 | ||||
| 8. Jornada | 18.09.2021 | Union Saint-Gilloise | - | SV Zulte Waregem | 2:1 | |
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| 9. Jornada | 25.09.2021 | SV Zulte Waregem | - | KV Kortrijk | 2:2 | |
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| 10. Jornada | 03.10.2021 | RFC Seraing | - | SV Zulte Waregem | 5:1 | ||||
| 11. Jornada | 16.10.2021 | SV Zulte Waregem | - | Royal Antwerp FC | 2:1 | ||||
| 18. Jornada | 12.12.2021 | Club Brugge KV | - | SV Zulte Waregem | 3:0 | ||||
| 19. Jornada | 15.12.2021 | SV Zulte Waregem | - | Union Saint-Gilloise | 0:2 | ||||
| 20. Jornada | 18.12.2021 | SV Zulte Waregem | - | KV Mechelen | 3:2 | ||||
| 21. Jornada | 26.12.2021 | Standard Liège | - | SV Zulte Waregem | 0:1 | ||||
| 24. Jornada | 26.01.2022 | SV Zulte Waregem | - | Oud-Heverlee Leuven | 1:1 | ||||
| 25. Jornada | 29.01.2022 | K Beerschot VA | - | SV Zulte Waregem | 3:3 |
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