| 2. Jornada | 24.03.2021 | Gualaceo SC | - | Atlético Porteño | 3:0 | ||||
| 3. Jornada | 01.04.2021 | Chacaritas FC | - | Gualaceo SC | 2:0 |  |
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| 4. Jornada | 07.04.2021 | Gualaceo SC | - | Guayaquil SC | 2:0 | ||||
| 5. Jornada | 14.04.2021 | Independiente Juniors | - | Gualaceo SC | 2:0 |  |
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| 6. Jornada | 21.04.2021 | Atlético Santo Domingo | - | Gualaceo SC | 1:0 | ||||
| 10. Jornada | 26.05.2021 | Atlético Porteño | - | Gualaceo SC | 3:1 | ||||
| 15. Jornada | 17.06.2021 | El Nacional | - | Gualaceo SC | 1:1 | ||||
| 17. Jornada | 25.06.2021 | América de Quito | - | Gualaceo SC | 0:1 | ||||
| 19. Jornada | 03.07.2021 | Atlético Santo Domingo | - | Gualaceo SC | 1:4 | ||||
| 20. Jornada | 09.07.2021 | Independiente Juniors | - | Gualaceo SC | 1:3 | |
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| 21. Jornada | 11.07.2021 | Gualaceo SC | - | Guayaquil SC | 2:0 | ||||
| 23. Jornada | 18.07.2021 | Gualaceo SC | - | Atlético Porteño | 4:2 | ||||
| 24. Jornada | 22.07.2021 | Cumbayá | - | Gualaceo SC | 2:1 | ||||
| 30. Jornada | 01.09.2021 | Gualaceo SC | - | Chacaritas FC | 0:1 | |
Ecuador