| 3. Jornada | 08.08.2021 | RSC Anderlecht | - | RFC Seraing | 3:0 | ||||
| 7. Jornada | 12.09.2021 | RSC Anderlecht | - | KV Mechelen | 7:2 | ||||
| 8. Jornada | 19.09.2021 | Standard Liège | - | RSC Anderlecht | 0:1 | ||||
| 11. Jornada | 17.10.2021 | Sint-Truidense VV | - | RSC Anderlecht | 2:2 | ||||
| 13. Jornada | 31.10.2021 | RSC Anderlecht | - | Oud-Heverlee Leuven | 2:2 | ||||
| 14. Jornada | 07.11.2021 | Royal Antwerp FC | - | RSC Anderlecht | 2:0 | ||||
| 15. Jornada | 21.11.2021 | RSC Anderlecht | - | KV Kortrijk | 1:1 | ||||
| 18. Jornada | 11.12.2021 | RFC Seraing | - | RSC Anderlecht | 0:5 | ||||
| 21. Jornada | 27.12.2021 | K Beerschot VA | - | RSC Anderlecht | 0:7 | ||||
| 25. Jornada | 30.01.2022 | Union Saint-Gilloise | - | RSC Anderlecht | 1:0 | ||||
| 30. Jornada | 06.03.2022 | RSC Anderlecht | - | KV Oostende | 3:0 | ||||
| 31. Jornada | 13.03.2022 | RSC Anderlecht | - | Royal Antwerp FC | 2:1 | ||||
| 33. Jornada | 03.04.2022 | RSC Anderlecht | - | Sporting Charleroi | 4:0 | ||||
| 34. Jornada | 10.04.2022 | KV Kortrijk | - | RSC Anderlecht | 2:3 |
Ucrania