| 21. Jornada | 28.02.2022 | FK Pelister | - | FK Renova | 1:1 | ||||
| 24. Jornada | 19.03.2022 | FK Pelister | - | FK Bregalnica Štip | 2:0 | ||||
| 28. Jornada | 16.04.2022 | FK Pelister | - | KF Shkupi | 0:1 | ||||
| 29. Jornada | 23.04.2022 | FC Struga | - | FK Pelister | 4:0 | ||||
| 30. Jornada | 01.05.2022 | FK Pelister | - | GFK Tikvesh | 1:1 | ||||
| 31. Jornada | 04.05.2022 | FK Skopje | - | FK Pelister | 4:2 | ||||
| 32. Jornada | 08.05.2022 | FK Pelister | - | FK Borec | 2:1 |
Macedonia del Norte