| 6. Jornada | 12.09.2021 | Servette FC | - | FC St. Gallen | 5:1 | ||||
| 7. Jornada | 22.09.2021 | FC St. Gallen | - | Basilea | 0:2 | ||||
| 8. Jornada | 25.09.2021 | BSC Young Boys | - | FC St. Gallen | 2:1 | ||||
| 9. Jornada | 02.10.2021 | Grasshopper Club Zürich | - | FC St. Gallen | 5:2 | ||||
| 10. Jornada | 17.10.2021 | FC St. Gallen | - | Servette FC | 2:1 | ||||
| 11. Jornada | 24.10.2021 | FC Luzern | - | FC St. Gallen | 2:0 |  |
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| 12. Jornada | 30.10.2021 | FC St. Gallen | - | BSC Young Boys | 3:1 | ||||
| 13. Jornada | 07.11.2021 | Basilea | - | FC St. Gallen | 0:1 | ||||
| 14. Jornada | 21.11.2021 | FC St. Gallen | - | FC Lausanne-Sport | 0:1 | ||||
| 15. Jornada | 27.11.2021 | FC Sion | - | FC St. Gallen | 3:1 | ||||
| 16. Jornada | 05.12.2021 | FC St. Gallen | - | Grasshopper Club Zürich | 0:4 | ||||
| 17. Jornada | 11.12.2021 | FC St. Gallen | - | FC Lugano | 1:1 | ||||
| 18. Jornada | 18.12.2021 | FC Zürich | - | FC St. Gallen | 3:1 |
Senegal