| 1. Jornada | 06.01.2019 | Lobos BUAP | - | Santos Laguna | 2:0 |  |
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| 2. Jornada | 14.01.2019 | Santos Laguna | - | Monarcas Morelia | 1:0 | ||||
| 3. Jornada | 19.01.2019 | Puebla FC | - | Santos Laguna | 1:1 | ||||
| 4. Jornada | 28.01.2019 | Santos Laguna | - | Deportivo Guadalajara | 1:0 | ||||
| 5. Jornada | 03.02.2019 | UANL Tigres | - | Santos Laguna | 2:1 | ||||
| 10. Jornada | 09.03.2019 | CD Veracruz | - | Santos Laguna | 2:2 | ||||
| 12. Jornada | 30.03.2019 | Atlas Guadalajara | - | Santos Laguna | 1:0 |
México