| 2. Jornada | 15.03.2021 | Blooming | - | Independiente Petrolero | 2:2 | ||||
| 1. Jornada | 20.03.2021 | Independiente Petrolero | - | Oriente Petrolero | 1:0 |  |
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| 3. Jornada | 04.04.2021 | Independiente Petrolero | - | The Strongest | 2:2 | ||||
| 4. Jornada | 12.04.2021 | Bolívar | - | Independiente Petrolero | 1:0 | ||||
| 14. Jornada | 08.08.2021 | Nacional Potosí | - | Independiente Petrolero | 1:2 | ||||
| 25. Jornada | 01.11.2021 | Independiente Petrolero | - | Club San José | 4:0 | |
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| 27. Jornada | 28.11.2021 | Independiente Petrolero | - | Real Santa Cruz | 2:1 |
Bolivia