| 11. Jornada | 16.10.2021 | FK Senica | - | MFK Zemplín Michalovce | 1:1 | ||||
| 13. Jornada | 30.10.2021 | MFK Zemplín Michalovce | - | FK Pohronie | 0:2 |  |
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| 14. Jornada | 05.11.2021 | AS Trenčín | - | MFK Zemplín Michalovce | 4:2 |  |
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| 15. Jornada | 21.11.2021 | MFK Zemplín Michalovce | - | Slovan Bratislava | 1:2 | ||||
| 18. Jornada | 10.12.2021 | Spartak Trnava | - | MFK Zemplín Michalovce | 2:0 | ||||
| 20. Jornada | 11.02.2022 | MFK Zemplín Michalovce | - | ŠKF Sereď | 0:1 | ||||
| 21. Jornada | 19.02.2022 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:1 | ||||
| 22. Jornada | 26.02.2022 | MFK Zemplín Michalovce | - | FK Senica | 0:1 |
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