| 1. Jornada | 20.11.2021 | Perth Glory | - | Adelaide United | 1:1 |  |
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| 2. Jornada | 26.11.2021 | Western United | - | Perth Glory | 1:0 | ||||
| 3. Jornada | 05.12.2021 | Melbourne Victory | - | Perth Glory | 0:3 | |
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| 4. Jornada | 08.12.2021 | Melbourne City FC | - | Perth Glory | 1:0 | |
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| 5. Jornada | 19.01.2022 | Brisbane Roar | - | Perth Glory | 1:0 | ||||
| 7. Jornada | 22.01.2022 | Sydney FC | - | Perth Glory | 1:2 | |
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| 14. Jornada | 13.02.2022 | Central Coast Mariners | - | Perth Glory | 1:1 | ||||
| 15. Jornada | 20.02.2022 | Perth Glory | - | Brisbane Roar | 2:0 | |
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| 12. Jornada | 23.02.2022 | Perth Glory | - | Macarthur FC | 0:1 | ||||
| 16. Jornada | 27.02.2022 | Perth Glory | - | Western United | 0:2 | ||||
| 13. Jornada | 02.03.2022 | Melbourne City FC | - | Perth Glory | 2:2 | |
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| 17. Jornada | 06.03.2022 | Perth Glory | - | Adelaide United | 1:2 | |
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| 26. Jornada | 12.03.2022 | Perth Glory | - | Sydney FC | 0:2 | |
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| 18. Jornada | 15.03.2022 | Perth Glory | - | Central Coast Mariners | 0:0 | ||||
| 19. Jornada | 19.03.2022 | Perth Glory | - | Brisbane Roar | 1:4 | ||||
| 21. Jornada | 30.04.2022 | Perth Glory | - | Western Sydney Wanderers | 1:1 | |
Uruguay