| 16. Jornada | 17.10.2021 | Guadalupe | - | Municipal Pérez Zeledón | 0:1 | ||||
| 17. Jornada | 23.10.2021 | Municipal Pérez Zeledón | - | Municipal Grecia | 3:1 |  |
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| 18. Jornada | 28.10.2021 | Municipal Pérez Zeledón | - | AD Guanacasteca | 2:0 | ||||
| 19. Jornada | 31.10.2021 | Santos de Guápiles | - | Municipal Pérez Zeledón | 3:2 | ||||
| 20. Jornada | 20.11.2021 | Municipal Pérez Zeledón | - | CS Cartaginés | 3:0 | ||||
| 21. Jornada | 24.11.2021 | Municipal Pérez Zeledón | - | Sporting FC | 1:0 | ||||
| 22. Jornada | 28.11.2021 | LD Alajuelense | - | Municipal Pérez Zeledón | 3:0 |
Brasil