| 3. Jornada | 15.08.2021 | Lobos UPNFM | - | Honduras Progreso | 3:0 |  |
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| 6. Jornada | 29.08.2021 | Honduras Progreso | - | Vida | 1:1 | ||||
| 8. Jornada | 12.09.2021 | Real Sociedad | - | Honduras Progreso | 1:0 | ||||
| 14. Jornada | 17.10.2021 | Honduras Progreso | - | Lobos UPNFM | 0:1 |  |
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| 15. Jornada | 24.10.2021 | Honduras Progreso | - | Olimpia | 0:2 | ||||
| 16. Jornada | 28.10.2021 | Real España | - | Honduras Progreso | 4:1 | ||||
| 17. Jornada | 01.11.2021 | Honduras Progreso | - | Real Sociedad | 2:1 | ||||
| 18. Jornada | 10.11.2021 | Motagua | - | Honduras Progreso | 3:2 |
Honduras