| 2. Jornada | 01.08.2021 | Bogotá FC | - | Barranquilla FC | 2:0 | ||||
| 4. Jornada | 16.08.2021 | Orsomarso SC | - | Barranquilla FC | 0:0 | ||||
| 11. Jornada | 03.10.2021 | Barranquilla FC | - | Boca Juniors de Cali | 1:0 |  |
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| 13. Jornada | 19.10.2021 | Barranquilla FC | - | Leones FC | 0:1 | ||||
| 14. Jornada | 24.10.2021 | Llaneros FC | - | Barranquilla FC | 4:2 | ||||
| 15. Jornada | 30.10.2021 | Barranquilla FC | - | Tigres FC | 2:0 |
Colombia