| 1. Jornada | 01.08.2021 | Alianza | - | Municipal Limeño | 4:1 | ||||
| 2. Jornada | 08.08.2021 | Platense Zacatecoluca | - | Alianza | 2:2 |  |
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| 3. Jornada | 11.08.2021 | AD Chalatenango | - | Alianza | 2:1 | ||||
| 6. Jornada | 26.08.2021 | Alianza | - | FAS | 1:0 | |
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| 9. Jornada | 16.09.2021 | Santa Tecla FC | - | Alianza | 0:4 | ||||
| 10. Jornada | 19.09.2021 | Alianza | - | CD Águila | 2:1 |  |
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| 13. Jornada | 17.10.2021 | Alianza | - | Platense Zacatecoluca | 4:0 | ||||
| 14. Jornada | 21.10.2021 | Alianza | - | AD Chalatenango | 1:0 | ||||
| 15. Jornada | 24.10.2021 | Luis Ángel Firpo | - | Alianza | 2:1 | ||||
| 16. Jornada | 30.10.2021 | Once Municipal | - | Alianza | 2:3 | |
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| 17. Jornada | 02.11.2021 | FAS | - | Alianza | 0:1 | |
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| 22. Jornada | 27.11.2021 | Alianza | - | Jocoro FC | 2:0 |
El Salvador