| 8. Jornada | 24.09.2021 | VVV-Venlo | - | Helmond Sport | 1:0 | ||||
| 9. Jornada | 01.10.2021 | Helmond Sport | - | Jong Ajax | 3:1 | ||||
| 10. Jornada | 10.10.2021 | FC Dordrecht | - | Helmond Sport | 0:1 | ||||
| 12. Jornada | 22.10.2021 | Telstar | - | Helmond Sport | 2:2 | ||||
| 13. Jornada | 01.11.2021 | Helmond Sport | - | Almere City FC | 1:2 | ||||
| 14. Jornada | 05.11.2021 | Helmond Sport | - | Roda JC Kerkrade | 0:3 | ||||
| 17. Jornada | 27.11.2021 | NAC Breda | - | Helmond Sport | 1:0 | ||||
| 18. Jornada | 03.12.2021 | Helmond Sport | - | FC Volendam | 1:1 | ||||
| 23. Jornada | 21.01.2022 | Helmond Sport | - | TOP Oss | 1:3 | ||||
| 27. Jornada | 14.03.2022 | Helmond Sport | - | VVV-Venlo | 0:3 | ||||
| 31. Jornada | 18.03.2022 | Helmond Sport | - | NAC Breda | 4:0 | ||||
| 32. Jornada | 26.03.2022 | SBV Excelsior | - | Helmond Sport | 3:0 | ||||
| 33. Jornada | 01.04.2022 | Helmond Sport | - | MVV | 1:2 | ||||
| 34. Jornada | 08.04.2022 | ADO Den Haag | - | Helmond Sport | 2:1 |  |
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| 35. Jornada | 15.04.2022 | Roda JC Kerkrade | - | Helmond Sport | 5:3 | ||||
| 36. Jornada | 22.04.2022 | Helmond Sport | - | De Graafschap | 0:4 | |
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| 37. Jornada | 29.04.2022 | AZ Alkmaar (J) | - | Helmond Sport | 0:1 | ||||
| 38. Jornada | 06.05.2022 | Helmond Sport | - | FC Den Bosch | 1:1 |
Países Bajos