| 24. Jornada | 27.01.2022 | Club Brugge KV | - | Union Saint-Gilloise | 0:0 |  |
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| 25. Jornada | 30.01.2022 | Union Saint-Gilloise | - | RSC Anderlecht | 1:0 | ||||
| 27. Jornada | 13.02.2022 | Union Saint-Gilloise | - | Sint-Truidense VV | 0:1 | ||||
| 28. Jornada | 19.02.2022 | Sporting Charleroi | - | Union Saint-Gilloise | 0:3 | |
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| 29. Jornada | 26.02.2022 | Union Saint-Gilloise | - | KAS Eupen | 0:0 | ||||
| 30. Jornada | 05.03.2022 | KV Kortrijk | - | Union Saint-Gilloise | 2:3 | ||||
| 33. Jornada | 03.04.2022 | Standard Liège | - | Union Saint-Gilloise | 1:3 |
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