| 4. Jornada | 13.02.2022 | Leones FC | - | Tigres FC | 3:1 |  |
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| 1. Jornada | 17.02.2022 | Boyacá Chicó | - | Leones FC | 1:0 | ||||
| 5. Jornada | 19.02.2022 | Fortaleza FC | - | Leones FC | 1:2 | ||||
| 6. Jornada | 27.02.2022 | Leones FC | - | Barranquilla FC | 3:1 | ||||
| 7. Jornada | 07.03.2022 | Atlético Huila | - | Leones FC | 1:1 | ||||
| 8. Jornada | 10.03.2022 | Leones FC | - | Real Cartagena | 1:0 | ||||
| 9. Jornada | 21.03.2022 | Real Santander | - | Leones FC | 0:4 | ||||
| 10. Jornada | 26.03.2022 | Leones FC | - | Atlético FC | 1:1 | ||||
| 13. Jornada | 18.04.2022 | Leones FC | - | Orsomarso SC | 3:1 | |
Colombia