| 1. Jornada | 26.07.2020 | Cruz Azul | - | Santos Laguna | 2:0 | ||||
| 2. Jornada | 03.08.2020 | Santos Laguna | - | Deportivo Guadalajara | 2:0 | ||||
| 3. Jornada | 09.08.2020 | CF Monterrey | - | Santos Laguna | 2:2 | ||||
| 4. Jornada | 14.08.2020 | CF América | - | Santos Laguna | 3:1 | ||||
| 5. Jornada | 17.08.2020 | Santos Laguna | - | Atlas Guadalajara | 0:0 | ||||
| 6. Jornada | 22.08.2020 | Club Necaxa | - | Santos Laguna | 2:1 | ||||
| 7. Jornada | 31.08.2020 | Santos Laguna | - | Gallos Blancos | 2:1 | ||||
| 8. Jornada | 05.09.2020 | FC Juárez | - | Santos Laguna | 1:1 | ||||
| 9. Jornada | 10.09.2020 | Santos Laguna | - | Pumas UNAM | 1:2 | ||||
| 10. Jornada | 13.09.2020 | UANL Tigres | - | Santos Laguna | 2:0 | ||||
| 11. Jornada | 20.09.2020 | Deportivo Toluca | - | Santos Laguna | 1:2 | ||||
| 13. Jornada | 03.10.2020 | Puebla FC | - | Santos Laguna | 0:2 | ||||
| 12. Jornada | 12.10.2020 | Santos Laguna | - | Club Tijuana | 2:0 | ||||
| 14. Jornada | 19.10.2020 | Santos Laguna | - | CF Pachuca | 1:1 | ||||
| 15. Jornada | 26.10.2020 | Santos Laguna | - | Atlético San Luis | 2:1 | ||||
| 16. Jornada | 03.11.2020 | Club León | - | Santos Laguna | 2:1 | ||||
| 17. Jornada | 09.11.2020 | Santos Laguna | - | Mazatlán FC | 4:0 |
México