| 1. Jornada | 09.01.2021 | CF América [Sub 20] | - | Atlético San Luis [Sub 20] | 4:1 | ||||
| 9. Jornada | 04.03.2021 | Club Tijuana [Sub 20] | - | CF América [Sub 20] | 0:1 | ||||
| 13. Jornada | 03.04.2021 | CF América [Sub 20] | - | Club Necaxa [Sub 20] | 1:0 | ||||
| 15. Jornada | 17.04.2021 | CF América [Sub 20] | - | Cruz Azul [Sub 20] | 4:1 | ||||
| 16. Jornada | 25.04.2021 | Deportivo Toluca [Sub 20] | - | CF América [Sub 20] | 0:2 |  |
México