| 1. Jornada | 07.01.2022 | Puebla FC [Sub 20] | - | CF América [Sub 20] | 1:5 | ||||
| 8. Jornada | 01.03.2022 | CF América [Sub 20] | - | Gallos Blancos [Sub 20] | 2:0 | ||||
| 15. Jornada | 20.04.2022 | CF América [Sub 20] | - | Club León [Sub 20] | 2:1 | ||||
| 16. Jornada | 23.04.2022 | UANL Tigres [Sub 20] | - | CF América [Sub 20] | 3:1 | ||||
| 17. Jornada | 30.04.2022 | CF América [Sub 20] | - | Cruz Azul [Sub 20] | 2:0 |  |
México