| 2. Jornada | 01.08.2021 | Bogotá FC | - | Barranquilla FC | 2:0 |  |
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| 3. Jornada | 08.08.2021 | Barranquilla FC | - | Atlético FC | 1:1 | ||||
| 4. Jornada | 16.08.2021 | Orsomarso SC | - | Barranquilla FC | 0:0 | ||||
| 5. Jornada | 26.08.2021 | Barranquilla FC | - | Valledupar FC | 2:1 | |
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| 6. Jornada | 01.09.2021 | Boyacá Chicó | - | Barranquilla FC | 1:1 | ||||
| 7. Jornada | 05.09.2021 | Barranquilla FC | - | Fortaleza FC | 0:0 | ||||
| 8. Jornada | 11.09.2021 | Real Santander | - | Barranquilla FC | 1:1 | |
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| 9. Jornada | 19.09.2021 | Barranquilla FC | - | Cortuluá | 2:2 |  |
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| 10. Jornada | 26.09.2021 | Unión Magdalena | - | Barranquilla FC | 3:0 | ||||
| 11. Jornada | 03.10.2021 | Barranquilla FC | - | Boca Juniors de Cali | 1:0 | |
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| 13. Jornada | 19.10.2021 | Barranquilla FC | - | Leones FC | 0:1 | |
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| 14. Jornada | 24.10.2021 | Llaneros FC | - | Barranquilla FC | 4:2 | ||||
| 15. Jornada | 30.10.2021 | Barranquilla FC | - | Tigres FC | 2:0 | |
Colombia