| 12. Jornada | 03.09.2022 | CF Pachuca [Sub 20] | - | Santos Laguna [Sub 20] | 5:1 | ||||
| 13. Jornada | 06.09.2022 | Santos Laguna [Sub 20] | - | Club Necaxa [Sub 20] | 3:2 |  |
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| 14. Jornada | 10.09.2022 | Gallos Blancos [Sub 20] | - | Santos Laguna [Sub 20] | 2:2 | ||||
| 5. Jornada | 14.09.2022 | CF América [Sub 20] | - | Santos Laguna [Sub 20] | 1:0 | ||||
| 15. Jornada | 18.09.2022 | Santos Laguna [Sub 20] | - | FC Juárez [Sub 20] | 3:0 | ||||
| 4. Jornada | 22.09.2022 | Deportivo Toluca [Sub 20] | - | Santos Laguna [Sub 20] | 1:0 | ||||
| 17. Jornada | 02.10.2022 | Santos Laguna [Sub 20] | - | Mazatlán FC [Sub 20] | 2:3 |
México