| 4. Jornada | 14.08.2021 | Pumas UNAM [Sub 16] | - | Deportivo Toluca [Sub 16] | 3:3 | ||||
| 1. Jornada | 01.09.2021 | Deportivo Toluca [Sub 16] | - | FC Juárez [Sub 16] | 2:1 | ||||
| 8. Jornada | 11.09.2021 | Deportivo Toluca [Sub 16] | - | CF América [Sub 16] | 1:0 |  |
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| 2. Jornada | 15.09.2021 | Club Tijuana [Sub 16] | - | Deportivo Toluca [Sub 16] | 3:0 | ||||
| 10. Jornada | 25.09.2021 | Puebla FC [Sub 16] | - | Deportivo Toluca [Sub 16] | 2:2 |  |
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| 12. Jornada | 09.10.2021 | Gallos Blancos [Sub 16] | - | Deportivo Toluca [Sub 16] | 1:1 | ||||
| 17. Jornada | 13.11.2021 | Deportivo Toluca [Sub 16] | - | CF Pachuca [Sub 16] | 4:1 | |
México