| 1. Jornada | 09.01.2021 | Mazatlán FC | - | Club Necaxa | 3:2 |  |
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| 2. Jornada | 17.01.2021 | Pumas UNAM | - | Mazatlán FC | 3:0 | ||||
| 3. Jornada | 23.01.2021 | Mazatlán FC | - | Santos Laguna | 0:0 | ||||
| 4. Jornada | 30.01.2021 | Mazatlán FC | - | CF Pachuca | 1:0 | ||||
| 5. Jornada | 07.02.2021 | Deportivo Toluca | - | Mazatlán FC | 4:1 |  |
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| 6. Jornada | 13.02.2021 | Mazatlán FC | - | Atlético San Luis | 0:3 | ||||
| 7. Jornada | 20.02.2021 | FC Juárez | - | Mazatlán FC | 1:0 | ||||
| 11. Jornada | 14.03.2021 | UANL Tigres | - | Mazatlán FC | 1:2 | ||||
| 12. Jornada | 20.03.2021 | Mazatlán FC | - | CF América | 0:1 | |
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| 13. Jornada | 03.04.2021 | Puebla FC | - | Mazatlán FC | 3:1 | ||||
| 14. Jornada | 12.04.2021 | Club Tijuana | - | Mazatlán FC | 2:3 | ||||
| 15. Jornada | 17.04.2021 | Mazatlán FC | - | Atlas Guadalajara | 0:0 | |
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| 16. Jornada | 24.04.2021 | Mazatlán FC | - | Club León | 4:3 | ||||
| 17. Jornada | 02.05.2021 | CF Monterrey | - | Mazatlán FC | 1:0 |
México