| 1. Jornada | 23.07.2022 | CSD Municipal | - | Cobán Imperial | 1:4 |  |
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| 2. Jornada | 31.07.2022 | Achuapa | - | CSD Municipal | 1:0 | ||||
| 3. Jornada | 07.08.2022 | CSD Municipal | - | Iztapa | 1:0 | ||||
| 4. Jornada | 11.08.2022 | Antigua GFC | - | CSD Municipal | 0:3 |  |
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| 5. Jornada | 13.08.2022 | CSD Municipal | - | Deportivo Malacateco | 4:1 | ||||
| 6. Jornada | 21.08.2022 | Comunicaciones | - | CSD Municipal | 2:2 | |
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| 7. Jornada | 28.08.2022 | CSD Municipal | - | Deportivo Guastatoya | 0:0 | ||||
| 8. Jornada | 01.09.2022 | Deportivo Mixco | - | CSD Municipal | 1:4 | ||||
| 9. Jornada | 03.09.2022 | CSD Municipal | - | Xelaju MC | 1:1 | ||||
| 10. Jornada | 11.09.2022 | Santa Lucía | - | CSD Municipal | 1:0 | ||||
| 11. Jornada | 17.09.2022 | CSD Municipal | - | Deportivo Xinabajul | 2:0 | |
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| 13. Jornada | 01.10.2022 | CSD Municipal | - | Achuapa | 1:1 | ||||
| 14. Jornada | 09.10.2022 | Iztapa | - | CSD Municipal | 3:2 | ||||
| 15. Jornada | 16.10.2022 | CSD Municipal | - | Antigua GFC | 0:1 | ||||
| 17. Jornada | 29.10.2022 | CSD Municipal | - | Comunicaciones | 2:3 | ||||
| 16. Jornada | 09.11.2022 | Deportivo Malacateco | - | CSD Municipal | 1:0 | ||||
| 21. Jornada | 23.11.2022 | CSD Municipal | - | Santa Lucía | 2:0 | |
Guatemala