| 5. Jornada | 22.08.2021 | FC DAC 1904 | - | AS Trenčín | 1:1 | ||||
| 6. Jornada | 27.08.2021 | FK Pohronie | - | FC DAC 1904 | 0:3 | ||||
| 7. Jornada | 12.09.2021 | FC DAC 1904 | - | Slovan Bratislava | 1:1 | ||||
| 8. Jornada | 18.09.2021 | MFK Ružomberok | - | FC DAC 1904 | 1:2 |  |
|||
| 9. Jornada | 26.09.2021 | FC DAC 1904 | - | Spartak Trnava | 0:3 | ||||
| 10. Jornada | 01.10.2021 | FC DAC 1904 | - | Zlaté Moravce | 4:2 | ||||
| 11. Jornada | 16.10.2021 | MŠK Žilina | - | FC DAC 1904 | 0:2 | ||||
| 12. Jornada | 24.10.2021 | FC DAC 1904 | - | MFK Zemplín Michalovce | 1:0 | ||||
| 13. Jornada | 30.10.2021 | Tatran Liptovský Mikuláš | - | FC DAC 1904 | 1:0 | ||||
| 16. Jornada | 27.11.2021 | AS Trenčín | - | FC DAC 1904 | 0:1 | ||||
| 17. Jornada | 04.12.2021 | FC DAC 1904 | - | FK Pohronie | 2:0 | ||||
| 18. Jornada | 12.12.2021 | Slovan Bratislava | - | FC DAC 1904 | 0:0 | |
|||
| 19. Jornada | 17.12.2021 | FC DAC 1904 | - | MFK Ružomberok | 0:0 |
Panamá