| 1. Jornada | 06.02.2023 | Real Santa Cruz | - | Atlético Palmaflor | 2:1 | ||||
| 2. Jornada | 12.02.2023 | Real Tomayapo | - | Real Santa Cruz | 1:0 | ||||
| 4. Jornada | 25.02.2023 | Real Santa Cruz | - | CD Guabirá | 0:0 |  |
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| 5. Jornada | 04.03.2023 | Royal Pari | - | Real Santa Cruz | 1:1 | ||||
| 6. Jornada | 11.03.2023 | Real Santa Cruz | - | The Strongest | 1:1 | ||||
| 8. Jornada | 09.04.2023 | Real Santa Cruz | - | Blooming | 2:1 | ||||
| 9. Jornada | 17.04.2023 | Club Aurora | - | Real Santa Cruz | 1:1 | ||||
| 10. Jornada | 23.04.2023 | Real Santa Cruz | - | Libertad Gran Mamoré | 3:2 | ||||
| 11. Jornada | 30.04.2023 | Vaca Díez | - | Real Santa Cruz | 2:1 | ||||
| 12. Jornada | 06.05.2023 | Real Santa Cruz | - | Always Ready | 2:1 | |
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| 7. Jornada | 11.05.2023 | Oriente Petrolero | - | Real Santa Cruz | 0:1 | ||||
| 13. Jornada | 14.05.2023 | Jorge Wilstermann | - | Real Santa Cruz | 1:0 |  |
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| 16. Jornada | 04.06.2023 | Real Santa Cruz | - | Independiente Petrolero | 1:0 |  |
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Rep. Dominicana