| 4. Jornada | 14.08.2021 | Mazatlán FC [Sub 16] | - | CF Monterrey [Sub 16] | 1:0 | ||||
| 6. Jornada | 28.08.2021 | CF Monterrey [Sub 16] | - | UANL Tigres [Sub 16] | 1:1 | ||||
| 7. Jornada | 04.09.2021 | CF Monterrey [Sub 16] | - | Club Necaxa [Sub 16] | 1:0 | ||||
| 8. Jornada | 11.09.2021 | Atlético San Luis [Sub 16] | - | CF Monterrey [Sub 16] | 2:1 |  |
 |
||
| 10. Jornada | 25.09.2021 | CF Monterrey [Sub 16] | - | Mazatlán FC [Sub 16] | 4:0 | ||||
| 11. Jornada | 02.10.2021 | Atlas Guadalajara [Sub 16] | - | CF Monterrey [Sub 16] | 3:1 | ||||
| 12. Jornada | 09.10.2021 | CF Monterrey [Sub 16] | - | Atlético San Luis [Sub 16] | 3:1 | ||||
| 13. Jornada | 16.10.2021 | Santos Laguna [Sub 16] | - | CF Monterrey [Sub 16] | 1:1 | ||||
| 14. Jornada | 23.10.2021 | UANL Tigres [Sub 16] | - | CF Monterrey [Sub 16] | 0:0 | ||||
| 15. Jornada | 30.10.2021 | CF Monterrey [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 1:7 | ||||
| 17. Jornada | 13.11.2021 | CF Monterrey [Sub 16] | - | Club León [Sub 16] | 0:3 | ||||
| 18. Jornada | 20.11.2021 | Club Necaxa [Sub 16] | - | CF Monterrey [Sub 16] | 1:1 |
México