| 1. Jornada | 08.08.2021 | Vida | - | Lobos UPNFM | 1:1 | ||||
| 2. Jornada | 11.08.2021 | Marathón | - | Lobos UPNFM | 5:1 | ||||
| 6. Jornada | 31.08.2021 | Motagua | - | Lobos UPNFM | 0:0 | ||||
| 7. Jornada | 04.09.2021 | Lobos UPNFM | - | Victoria | 3:0 | ||||
| 8. Jornada | 12.09.2021 | Lobos UPNFM | - | Olimpia | 0:0 | ||||
| 9. Jornada | 15.09.2021 | Lobos UPNFM | - | Real Sociedad | 2:0 | ||||
| 10. Jornada | 20.09.2021 | Lobos UPNFM | - | Motagua | 2:2 |  |
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| 12. Jornada | 04.10.2021 | Lobos UPNFM | - | Marathón | 1:1 |  |
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| 14. Jornada | 17.10.2021 | Honduras Progreso | - | Lobos UPNFM | 0:1 | ||||
| 15. Jornada | 25.10.2021 | Lobos UPNFM | - | Real España | 1:2 | ||||
| 18. Jornada | 10.11.2021 | Victoria | - | Lobos UPNFM | 1:0 |
Honduras