| 1. Jornada | 20.01.2022 | Lobos UPNFM | - | Vida | 3:0 |  |
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| 2. Jornada | 23.01.2022 | Honduras Progreso | - | Lobos UPNFM | 1:2 | ||||
| 3. Jornada | 06.02.2022 | Real Sociedad | - | Lobos UPNFM | 2:2 | ||||
| 4. Jornada | 10.02.2022 | Lobos UPNFM | - | Platense | 1:2 | ||||
| 6. Jornada | 21.02.2022 | Lobos UPNFM | - | Motagua | 0:0 | ||||
| 7. Jornada | 27.02.2022 | Lobos UPNFM | - | Olimpia | 0:3 | ||||
| 8. Jornada | 03.03.2022 | Real España | - | Lobos UPNFM | 1:0 | ||||
| 9. Jornada | 07.03.2022 | Marathón | - | Lobos UPNFM | 4:1 | ||||
| 10. Jornada | 13.03.2022 | Lobos UPNFM | - | Real Sociedad | 1:0 | ||||
| 11. Jornada | 20.03.2022 | Lobos UPNFM | - | Honduras Progreso | 2:2 | |
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| 12. Jornada | 03.04.2022 | Platense | - | Lobos UPNFM | 1:0 | ||||
| 13. Jornada | 07.04.2022 | Lobos UPNFM | - | Victoria | 0:3 | ||||
| 14. Jornada | 11.04.2022 | Motagua | - | Lobos UPNFM | 2:0 |  |
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| 15. Jornada | 14.04.2022 | Lobos UPNFM | - | Real España | 0:2 | ||||
| 16. Jornada | 21.04.2022 | Vida | - | Lobos UPNFM | 4:2 | |
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| 17. Jornada | 25.04.2022 | Olimpia | - | Lobos UPNFM | 0:1 | ||||
| 18. Jornada | 01.05.2022 | Lobos UPNFM | - | Marathón | 1:2 |
Honduras