| 1. Jornada | 31.07.2022 | Real Sociedad | - | Marathón | 0:2 | ||||
| 2. Jornada | 07.08.2022 | Honduras Progreso | - | Marathón | 0:2 |  |
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| 3. Jornada | 11.08.2022 | Marathón | - | Olimpia | 1:2 | |
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| 4. Jornada | 15.08.2022 | Motagua | - | Marathón | 4:1 | ||||
| 5. Jornada | 20.08.2022 | Marathón | - | Vida | 4:4 | ||||
| 8. Jornada | 04.09.2022 | Marathón | - | Lobos UPNFM | 1:1 | ||||
| 10. Jornada | 18.09.2022 | Marathón | - | Real Sociedad | 3:0 | ||||
| 11. Jornada | 01.10.2022 | Marathón | - | Honduras Progreso | 5:1 |  |
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| 12. Jornada | 09.10.2022 | Olimpia | - | Marathón | 1:0 | ||||
| 13. Jornada | 15.10.2022 | Marathón | - | Motagua | 2:2 | ||||
| 15. Jornada | 23.10.2022 | Marathón | - | Real España | 2:0 | ||||
| 16. Jornada | 06.11.2022 | Victoria | - | Marathón | 2:1 | ||||
| 18. Jornada | 19.11.2022 | Marathón | - | Olancho FC | 4:0 |  |
Honduras