| 1. Jornada | 26.07.2021 | Cruz Azul [Sub 20] | - | Mazatlán FC [Sub 20] | 1:1 | ||||
| 3. Jornada | 06.08.2021 | Mazatlán FC [Sub 20] | - | CF Monterrey [Sub 20] | 1:4 | ||||
| 4. Jornada | 14.08.2021 | Club León [Sub 20] | - | Mazatlán FC [Sub 20] | 1:0 | ||||
| 5. Jornada | 17.08.2021 | Deportivo Toluca [Sub 20] | - | Mazatlán FC [Sub 20] | 3:1 |  |
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| 6. Jornada | 20.08.2021 | Mazatlán FC [Sub 20] | - | UANL Tigres [Sub 20] | 3:2 | ||||
| 7. Jornada | 27.08.2021 | Mazatlán FC [Sub 20] | - | Atlético San Luis [Sub 20] | 3:1 | ||||
| 15. Jornada | 22.10.2021 | Mazatlán FC [Sub 20] | - | Gallos Blancos [Sub 20] | 4:0 | ||||
| 17. Jornada | 05.11.2021 | Mazatlán FC [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:0 |
México