| 1. Jornada | 08.01.2012 | Santos Laguna | - | CF Pachuca | 0:0 |  |
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| 6. Jornada | 11.02.2012 | Monarcas Morelia | - | Santos Laguna | 3:1 |  |
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| 7. Jornada | 19.02.2012 | Santos Laguna | - | CF Monterrey | 1:1 | ||||
| 8. Jornada | 26.02.2012 | Deportivo Guadalajara | - | Santos Laguna | 2:1 | ||||
| 9. Jornada | 04.03.2012 | Santos Laguna | - | Club San Luis | 5:2 | |
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| 11. Jornada | 18.03.2012 | Cruz Azul | - | Santos Laguna | 0:1 | |
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| 15. Jornada | 15.04.2012 | CF América | - | Santos Laguna | 3:1 | ||||
| 16. Jornada | 22.04.2012 | Santos Laguna | - | UANL Tigres | 3:0 |
México