| 1. Jornada | 26.07.2015 | Santos Laguna | - | Club León | 1:3 |  |
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| 3. Jornada | 08.08.2015 | Santos Laguna | - | Club Tijuana | 0:1 | ||||
| 4. Jornada | 12.08.2015 | Gallos Blancos | - | Santos Laguna | 1:2 | ||||
| 7. Jornada | 29.08.2015 | Santos Laguna | - | Pumas UNAM | 3:4 | ||||
| 8. Jornada | 14.09.2015 | Puebla FC | - | Santos Laguna | 0:1 | ||||
| 17. Jornada | 23.11.2015 | Deportivo Guadalajara | - | Santos Laguna | 0:3 |  |
México