| 1. Jornada | 24.07.2021 | CF Monterrey [Sub 20] | - | Puebla FC [Sub 20] | 4:1 |  |
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| 2. Jornada | 31.07.2021 | CF Monterrey [Sub 20] | - | Pumas UNAM [Sub 20] | 3:1 | ||||
| 3. Jornada | 06.08.2021 | Mazatlán FC [Sub 20] | - | CF Monterrey [Sub 20] | 1:4 | ||||
| 4. Jornada | 14.08.2021 | CF Monterrey [Sub 20] | - | CF Pachuca [Sub 20] | 1:1 | ||||
| 6. Jornada | 21.08.2021 | CF Monterrey [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:1 | ||||
| 7. Jornada | 28.08.2021 | Club Tijuana [Sub 20] | - | CF Monterrey [Sub 20] | 1:0 | ||||
| 17. Jornada | 06.11.2021 | CF América [Sub 20] | - | CF Monterrey [Sub 20] | 2:0 |
México