| 2. Jornada | 26.01.2021 | Tigres FC | - | Unión Magdalena | 1:1 | ||||
| 3. Jornada | 31.01.2021 | Leones FC | - | Tigres FC | 1:2 | ||||
| 4. Jornada | 07.02.2021 | Tigres FC | - | Deportes Quindío | 1:1 | ||||
| 5. Jornada | 11.02.2021 | Atlético Huila | - | Tigres FC | 1:0 | ||||
| 6. Jornada | 15.02.2021 | Tigres FC | - | Orsomarso SC | 2:0 | ||||
| 7. Jornada | 20.02.2021 | Cortuluá | - | Tigres FC | 0:0 | ||||
| 8. Jornada | 28.02.2021 | Tigres FC | - | Boca Juniors de Cali | 1:1 | ||||
| 9. Jornada | 03.03.2021 | Atlético FC | - | Tigres FC | 0:1 | ||||
| 10. Jornada | 06.03.2021 | Tigres FC | - | Real Cartagena | 0:0 | ||||
| 11. Jornada | 13.03.2021 | Barranquilla FC | - | Tigres FC | 1:0 | ||||
| 12. Jornada | 21.03.2021 | Tigres FC | - | Real Santander | 1:1 |  |
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| 13. Jornada | 27.03.2021 | Valledupar FC | - | Tigres FC | 0:0 | ||||
| 14. Jornada | 05.04.2021 | Tigres FC | - | Bogotá FC | 0:2 | ||||
| 15. Jornada | 08.04.2021 | Tigres FC | - | Llaneros FC | 1:1 |
Colombia