| 1. Jornada | 06.02.2016 | Fénix | - | River Plate | 1:1 | ||||
| 2. Jornada | 13.02.2016 | River Plate | - | Nacional | 0:3 | ||||
| 3. Jornada | 21.02.2016 | Sud América | - | River Plate | 2:1 | ||||
| 4. Jornada | 27.02.2016 | River Plate | - | Montevideo Wanderers | 1:1 | ||||
| 5. Jornada | 06.03.2016 | Racing | - | River Plate | 0:1 | ||||
| 7. Jornada | 03.04.2016 | Peñarol | - | River Plate | 0:2 |  |
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| 8. Jornada | 10.04.2016 | River Plate | - | Juventud de Las Piedras | 0:0 | ||||
| 9. Jornada | 24.04.2016 | Danubio | - | River Plate | 0:3 | ||||
| 10. Jornada | 30.04.2016 | River Plate | - | CA Cerro | 3:1 | ||||
| 11. Jornada | 08.05.2016 | Rentistas | - | River Plate | 2:1 | ||||
| 14. Jornada | 29.05.2016 | River Plate | - | Defensor Sporting | 1:2 | ||||
| 15. Jornada | 05.06.2016 | Villa Teresa | - | River Plate | 2:0 |
Colombia