| 4. Jornada | 31.07.2021 | FC Floreşti | - | FC Sheriff | 1:3 | ||||
| 5. Jornada | 07.08.2021 | FC Sheriff | - | Dinamo-Auto | 7:1 | ||||
| 8. Jornada | 28.08.2021 | FC Bălţi | - | FC Sheriff | 0:2 | ||||
| 9. Jornada | 12.09.2021 | FC Sheriff | - | CS Petrocub | 2:0 | ||||
| 10. Jornada | 19.09.2021 | FC Zimbru | - | FC Sheriff | 1:1 | ||||
| 12. Jornada | 25.09.2021 | Dinamo-Auto | - | FC Sheriff | 0:7 |  |
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| 16. Jornada | 31.10.2021 | CS Petrocub | - | FC Sheriff | 0:2 | ||||
| 17. Jornada | 06.11.2021 | FC Sheriff | - | FC Zimbru | 6:0 | ||||
| 19. Jornada | 28.11.2021 | FC Sheriff | - | Dinamo-Auto | 7:0 | ||||
| 6. Jornada | 01.03.2022 | FC Sheriff | - | FC Milsami | 1:0 | ||||
| 20. Jornada | 13.03.2022 | FC Sheriff | - | FC Milsami | 0:1 | ||||
| 24. Jornada | 16.04.2022 | FC Zimbru | - | FC Sheriff | 1:1 | ||||
| 26. Jornada | 29.04.2022 | Dinamo-Auto | - | FC Sheriff | 0:3 | ||||
| 27. Jornada | 07.05.2022 | FC Milsami | - | FC Sheriff | 1:1 | ||||
| 28. Jornada | 14.05.2022 | FC Sheriff | - | FC Sfîntul Gheorghe | 2:0 |
Malawi