| 1. Jornada | 23.01.2016 | Club San José | - | Sport Boys Warnes | 1:1 | ||||
| 2. Jornada | 29.01.2016 | Club San José | - | Bolívar | 2:0 |  |
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| 3. Jornada | 31.01.2016 | Ciclón | - | Club San José | 1:0 | ||||
| 5. Jornada | 14.02.2016 | Blooming | - | Club San José | 2:1 | ||||
| 6. Jornada | 18.02.2016 | Club San José | - | Jorge Wilstermann | 1:3 |  |
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| 4. Jornada | 24.02.2016 | Club San José | - | Oriente Petrolero | 0:3 | ||||
| 8. Jornada | 06.03.2016 | Club San José | - | Real Potosí | 2:3 | |
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| 9. Jornada | 13.03.2016 | Nacional Potosí | - | Club San José | 1:1 | |
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| 16. Jornada | 30.04.2016 | Club San José | - | Blooming | 0:0 | ||||
| 17. Jornada | 05.05.2016 | Jorge Wilstermann | - | Club San José | 2:2 |  |
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| 19. Jornada | 12.05.2016 | Real Potosí | - | Club San José | 2:1 | ||||
| 20. Jornada | 15.05.2016 | The Strongest | - | Club San José | 4:1 | |
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| 22. Jornada | 25.05.2016 | Petrolero de Yacuiba | - | Club San José | 2:0 |
Brasil