| 2. Jornada | 21.08.2021 | Birkirkara FC | - | Hamrun Spartans | 2:1 | ||||
| 4. Jornada | 19.09.2021 | Hamrun Spartans | - | Balzan FC | 0:1 | ||||
| 7. Jornada | 23.10.2021 | Gudja United | - | Hamrun Spartans | 1:3 | ||||
| 10. Jornada | 28.11.2021 | Hamrun Spartans | - | St. Luċija FC | 3:0 | ||||
| 11. Jornada | 05.12.2021 | Sliema Wanderers | - | Hamrun Spartans | 0:2 | ||||
| 17. Jornada | 05.02.2022 | Gżira United | - | Hamrun Spartans | 4:1 | ||||
| 18. Jornada | 13.02.2022 | Hamrun Spartans | - | Gudja United | 0:1 | ||||
| 20. Jornada | 26.02.2022 | Hamrun Spartans | - | Hibernians FC | 0:0 | ||||
| 22. Jornada | 11.03.2022 | Hamrun Spartans | - | Sliema Wanderers | 3:1 |
Malta