| 1. Jornada | 25.07.2010 | Atlante | - | Santos Laguna | 1:4 |  |
|||
| 2. Jornada | 01.08.2010 | Santos Laguna | - | Pumas UNAM | 4:0 | |
|||
| 3. Jornada | 08.08.2010 | CF Pachuca | - | Santos Laguna | 0:3 | |
 |
||
| 4. Jornada | 15.08.2010 | Santos Laguna | - | Jaguares Chiapas | 1:0 | |
|
||
| 5. Jornada | 22.08.2010 | UANL Tigres | - | Santos Laguna | 1:0 | |
|||
| 6. Jornada | 29.08.2010 | Santos Laguna | - | Atlas Guadalajara | 3:1 | |
|||
| 7. Jornada | 12.09.2010 | Gallos Blancos (old) | - | Santos Laguna | 5:2 | |
|||
| 8. Jornada | 19.09.2010 | Santos Laguna | - | Club Necaxa | 2:1 | |
|
||
| 9. Jornada | 27.09.2010 | CF América | - | Santos Laguna | 3:2 | |
|||
| 10. Jornada | 03.10.2010 | Santos Laguna | - | Deportivo Toluca | 2:0 | |
|||
| 12. Jornada | 17.10.2010 | Cruz Azul | - | Santos Laguna | 3:0 | ||||
| 13. Jornada | 24.10.2010 | Santos Laguna | - | CF Monterrey | 1:2 | |
|
||
| 14. Jornada | 28.10.2010 | Puebla FC | - | Santos Laguna | 0:1 | ||||
| 15. Jornada | 31.10.2010 | Santos Laguna | - | Deportivo Guadalajara | 1:1 | |
|||
| 16. Jornada | 07.11.2010 | Club San Luis | - | Santos Laguna | 1:1 | |
|||
| 17. Jornada | 14.11.2010 | Santos Laguna | - | Estudiantes Tecos | 1:0 |
Ecuador