| 1. Jornada | 13.08.2021 | Hamrun Spartans | - | Valletta FC | 1:2 | ||||
| 2. Jornada | 21.08.2021 | Valletta FC | - | Balzan FC | 1:0 | ||||
| 3. Jornada | 11.09.2021 | Floriana FC | - | Valletta FC | 3:0 |  |
|||
| 5. Jornada | 25.09.2021 | Gudja United | - | Valletta FC | 2:0 | ||||
| 6. Jornada | 17.10.2021 | Valletta FC | - | Sirens FC | 3:1 | ||||
| 7. Jornada | 24.10.2021 | Hibernians FC | - | Valletta FC | 1:1 | ||||
| 8. Jornada | 30.10.2021 | Valletta FC | - | St. Luċija FC | 5:3 | ||||
| 17. Jornada | 06.02.2022 | Sirens FC | - | Valletta FC | 2:1 |  |
|||
| 18. Jornada | 12.02.2022 | Valletta FC | - | Hibernians FC | 1:4 | ||||
| 19. Jornada | 20.02.2022 | St. Luċija FC | - | Valletta FC | 2:1 | ||||
| 20. Jornada | 26.02.2022 | Valletta FC | - | Sliema Wanderers | 1:0 | ||||
| 21. Jornada | 05.03.2022 | Mosta FC | - | Valletta FC | 2:2 | |
|||
| 22. Jornada | 12.03.2022 | Birkirkara FC | - | Valletta FC | 1:1 |
Malta