| 1. Jornada | 01.08.2021 | Real Estelí FC | - | H&H Export Sébaco | 4:0 | ||||
| 2. Jornada | 10.08.2021 | UNAN Managua | - | H&H Export Sébaco | 0:2 |  |
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| 3. Jornada | 15.08.2021 | H&H Export Sébaco | - | Club Deportivo Ocotal | 0:1 | ||||
| 5. Jornada | 29.08.2021 | Juventus Managua | - | H&H Export Sébaco | 1:0 | ||||
| 6. Jornada | 03.09.2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 | ||||
| 8. Jornada | 19.09.2021 | Diriangén FC | - | H&H Export Sébaco | 1:0 | ||||
| 9. Jornada | 26.09.2021 | Real Madriz | - | H&H Export Sébaco | 3:3 | |
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| 10. Jornada | 02.10.2021 | H&H Export Sébaco | - | Real Estelí FC | 1:3 | ||||
| 11. Jornada | 10.10.2021 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
| 12. Jornada | 16.10.2021 | Club Deportivo Ocotal | - | H&H Export Sébaco | 1:1 | ||||
| 13. Jornada | 21.10.2021 | Managua FC | - | H&H Export Sébaco | 1:2 | ||||
| 14. Jornada | 23.10.2021 | H&H Export Sébaco | - | Juventus Managua | 3:3 | ||||
| 16. Jornada | 04.11.2021 | H&H Export Sébaco | - | ART Municipal Jalapa | 3:0 | ||||
| 17. Jornada | 17.11.2021 | H&H Export Sébaco | - | Diriangén FC | 1:1 | ||||
| 18. Jornada | 20.11.2021 | H&H Export Sébaco | - | Real Madriz | 2:3 |
Nicaragua