| 1. Jornada | 11.09.2021 | Panetolikos | - | Asteras Tripolis | 0:0 | ||||
| 4. Jornada | 26.09.2021 | Lamia | - | Panetolikos | 2:2 | ||||
| 6. Jornada | 17.10.2021 | Panetolikos | - | OFI Heraklion | 1:2 | ||||
| 7. Jornada | 24.10.2021 | Aris Saloniki | - | Panetolikos | 5:1 |  |
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| 16. Jornada | 12.01.2022 | PAOK Saloniki | - | Panetolikos | 2:0 | ||||
| 20. Jornada | 30.01.2022 | Panetolikos | - | Aris Saloniki | 0:2 | ||||
| 21. Jornada | 02.02.2022 | Olympiacos | - | Panetolikos | 3:1 |
Grecia